STAT1 and infection: It suggests that although miRNA changes are different, they may exert antiviral effects by regulating the expression of the same genes [2, 4]; In addition, in a study of microarray analysis after human nasal epithelial cells (hNECs) infection with human IAVs of H3N2 subtype, although identical DEMs were not found, more DEGs, such as IRF7, STAT1, CXCL10, and IL6, were found mainly triggered inflammatory reactions and innate immune responses in the transmission of signals such as interferon, JAK-STAT, and Toll like receptors, similar to the changes observed in our experiment [37].