LDHA and Familial prostate cancer: For example, circARHGAP29 triggers the docetaxel resistance and aerobic glycolysis in prostate cancer cells, and circARHGAP29 increases the lactate dehydrogenase A (LDHA) mRNA stability of strengthening its interaction to insulin-like growth factor 2 mRNA-binding protein 2, resulting in enhanced glycolytic metabolism [21].