Of note, in addition to its action on the ATP1A1 isoform, bufalin also modulates the translation of cancer-related proteins by indirectly acting on eIF4A and eIF4G through the strong inhibition of the transcriptional co-activator SRC-3 and of the transcription factor cMYC in triple-negative breast cancer [60]. The gene discussed is EIF4G1; the disease is triple-negative breast carcinoma.