However, the same group identified a crucial role of C5aR1 in the same model of LPS induced ARDS in mice [50] as well as in a model of immune complexes induced ARDS; the latter finding was initially reported earlier in a study which used a gene targeted disruption of the C5aR1 gene and immune complex mediated ARDS in mice [51]. Here, C5AR1 is linked to acute respiratory distress syndrome.