Moreover, a deficit in intracellular d-chiro-inositol (DCI) has been observed in women with PCOS and overweight or obesity, resulting in impaired coupling between insulin action and the release of d-chiro-inositol-containing inositolphosphoglycan (DCI-IPG) that acts as an insulin mediator and sensitizer [113]. The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.