CCL2 and Alzheimer disease: In contrast to our findings, and these findings from human AD tissue, cultured microglia from PSEN2 (N141I) knock-in mice exhibited a different range of chemokine release in response to Aβ42 not impacted in our PSEN2 (N141I)-derived microglia such as the significant upregulation of CCL2, CCL5 and CXCL1 [66].