IL18 and Alzheimer disease: Significantly increased secretion of IL-18 (1473 a.u ± 352 SD and 4299 a.u ± 2006 SD, healthy control and AD-derived, respectively) (p < 0.05) and macrophage migration inhibitory factor (MIF) (5483 a.u ± 1635 SD and 12,535 a.u ± 4742 SD, healthy control and AD-derived, respectively) (p < 0.01) were observed from AD-derived microglia-like cells compared to healthy controls after Aβ42 stimulation (Fig. 8D).