Indeed, while Cx43 and Panx1 have been related to microglia activation in the CNS [51], Cx30 and Cx26 are essential for hearing function, given that deletion of the GJB2 and GJB6 genes, encoding for Cx26 and Cx30, respectively, is the main cause of non-syndromic sensorineural hearing loss in the Mediterranean population [135–137]. The gene discussed is GJB2; the disease is sensorineural hearing loss disorder.