Furthermore, the lack of methyltransferase like 3 (METTL3) in monocytes derived macrophages improved Aβ caused cognitive function impairment in AD mice, which is due to METTL3 ablation attenuating the m6A modification in DNA methyltransferase 3A (Dnmt3a) mRNAs and consequently impairing YTH N6-methyladenosine RNA binding protein 1 (YTHDF1)-mediated translation of DNMT3A [97]. The gene discussed is DNMT3A; the disease is Alzheimer disease.