Our results of α7nAChR−/− mice compared with WT clearly demonstrate the detrimental impact of α7nAChR deficiency on survival during murine endotoxemia and complement previous observations that administration of the α7nAChR agonists GTS-21 or choline improve the survival of mice during endotoxemia and CLP sepsis [18, 19]. This evidence concerns the gene CHRNA7 and serum lipopolysaccharide activity.