Under latent EBV infection, intracellular ROS production increases P-gp expression via the STAT1 pathway, and ROS scavenger NecroX-5 down-regulates ROS, effectively attenuating P-gp-associated chemotherapy resistance in EBV-positive NK/ T-cell lymphoma. The gene discussed is PGP; the disease is T-cell non-Hodgkin lymphoma.