Although the mechanism needs to be further investigated, GEP studies suggest increased expression of NF-κB-related genes in PTCL and that NF-κb inhibitors induce apoptosis in PTCL cells [82], findings that support the hypothesis that this pathway plays an important role in PTCL. This evidence concerns the gene NFKB1 and mature T-cell and NK-cell non-Hodgkin lymphoma.