In conclusion, our findings showed that daily supplementation of 2000 mg of NS oil after 2 periods of 8 weeks resulted in significant reductions in blood mRNA expression levels of obesity-related pro-inflammatory genes, including IL-6, IL-1β, and leptin. Serum levels of IL-6, IL-1β, leptin, and insulin were also significantly reduced but the changes in insulin levels are of minor clinical significance. Here, IL1B is linked to obesity due to melanocortin 4 receptor deficiency.