Moreover, ZnONP nanocomposites (ZnONPs, ZnONPs/DOX, ZnONPs/FA and ZnONPs/DOX/FA) exerted cytoprotective effects against ischemic liver injury and kidney injury this renoprotective and hepatoprotective effects might be due to the oxidative stress inhibition, enhancement of cell proliferation, up-regulation of anti-oxidant genes and down-regulation of inflammatory cytokine TNF-α and apoptotic genes caspase-3 and Bax [87]. The gene discussed is CASP3; the disease is injury.