Considering the involvement of apelin and TGF-β signaling pathways in diabetic nephropathy and liver damage, as well as the ameliorating effects of MSCs-conditioned media therapy on liver and kidney diseases, the present study aims to investigate the protective effects of hWJ-MSCs-CM through the mentioned signaling pathways on the renal and hepatic complications of diabetes. The gene discussed is APLN; the disease is diabetic kidney disease.