HTR5A and migraine disorder: Moreover, our study identified the risk factors and protective factors in TRP metabolites for pediatric migraine, showing that KYN, KYNA, KYN/TRP, KYNA/KYN, and KYNA/QUIN play a protective role in pediatric migraine, and TRP, 5-HT, QUIN, QUIN/KYN and age play a risk role in pediatric migraine.