These drugs include the cell cycle inhibitors Trabectedin (a natural product that covalently modifies guanine bases of DNA and is a first-line chemodrug for the treatment of sarcoma), Dinaciclib (a multi-CDK inhibitor, blocking the cell cycle), Volasertib (a PLK1 inhibitor interfering with mitosis) as well as a series of multi-kinase inhibitors (Fig. 2A,B). The gene discussed is PLK1; the disease is sarcoma.