EWSR1 and Ewing sarcoma: As the two Ewing sarcoma lines in our panel were susceptible to AURK and PARP inhibitors in our and prior screens (Fig. EV4E) (Garnett et al, 2012; Teicher et al, 2015), the data suggests that the sensitivity to AURK and PARP inhibitors in this cluster might be triggered by an EWS/FLI-regulated signalling pathway (Ihnen et al, 2013).