Dinaciclib (a multi-CDK inhibitor) also only had a small phenotypic effect on SW684 cells, In fact, the computed CDK1 activity in SW684 cells was the lowest of all cell lines and SW684 cells were the least Dinaciclib-responsive of all 17 sarcoma lines (Fig. EV3E, right panel). The gene discussed is CDK1; the disease is sarcoma.