STING1 and early-onset autosomal dominant Alzheimer disease: While the cGAS/STING pathway is critical for innate immunity, abnormal activation of this pathway has been increasingly implicated in various human diseases including Parkinson’s and Alzheimer’s diseases, as well as normal aging (Gulen et al, 2023; Sliter et al, 2018; Udeochu et al, 2023).