FANCM and Fanconi anemia: Of note, the authors of this study have proposed that AND-1 initiates the Fanconi anemia pathway by sensing and specifically binding DNA ICLs through its C-terminal HMG domain: threonine 826 phosphorylation would elicit an AND-1 conformational change that enhances affinity of the HMG domain for DNA ICLs promoting FANCM/FAAP24 recruitment to these damaged sites.