BRIP1 and cancer: Through data mining of cancer genomics databases (cBioPortal, http://cbioportal.org, Cosmic-3D, https://cancer.sanger.ac.uk/cosmic3d, and gnomAD, https://gnomad.broadinstitute.org) we pinpointed FANCJ variants expected to give rise to mutations of CIP box amino-acid residues in various malignancies, including uterine endometrial carcinoma (N734H), invasive breast carcinoma (D736H), breast and ovarian cancer (Q740H), glioblastoma multiforme (Y743C), and colorectal adenocarcinoma (A745T) (Fig. 6A).