Through data mining of cancer genomics databases (cBioPortal, http://cbioportal.org, Cosmic-3D, https://cancer.sanger.ac.uk/cosmic3d, and gnomAD, https://gnomad.broadinstitute.org) we pinpointed FANCJ variants expected to give rise to mutations of CIP box amino-acid residues in various malignancies, including uterine endometrial carcinoma (N734H), invasive breast carcinoma (D736H), breast and ovarian cancer (Q740H), glioblastoma multiforme (Y743C), and colorectal adenocarcinoma (A745T) (Fig. 6A). Here, BRIP1 is linked to invasive breast carcinoma.