VCP and frontotemporal dementia: Studies have shown that p97 mutation can disrupt p97-adaptor binding which has been causally linked to multisystem proteinopathy 1 (MSP-1), a degenerative disorder wherein individuals present with inclusion body myopathy, Paget’s disease of the bone and/or frontotemporal dementia (Buchberger et al, 2015; Zhang et al, 2015; Weihl et al, 2006, Watts et al, 2004; Schroder et al, 2005).