In Apoe-/- mice following RI/MI, both HHcy and hyperglycemia dramatically increased the infarction size of hearts (Appendix Fig. S7b,c) and plasma cTn-I level (Appendix Fig. S7d), and induced nitrosative stress (Appendix Fig. S8a,b), and worsened cardiac dysfunctions (Appendix Table S2). Here, TNNI3 is linked to Hyperglycemia.