As expected, HHcy and hyperglycemia significantly decreased CCBF (Fig. 7A) and ex vivo coronary flow (Appendix Table S2), lowered serum omentin-1 levels (Fig. 7B), and inhibited the maturation of pre-existing arteries in collateral area and vascular contractile phenotypic restoration (Fig. 7C–E) in Apoe-/- mice following MI, rather than Apoe-/-/iNOSsm-/- mice. This evidence concerns the gene APOE and Hyperglycemia.