ALAS1 and metabolic dysfunction-associated steatotic liver disease: ALKBH7, ACSF3, MLYCD, and CRAT have been reported to be direct regulators of NAFLD (Derdak et al, 2013; Solberg et al, 2013; Sun et al, 2020; Wallace et al, 2018; Wang et al, 2014a), while NUDT19, MMUT, and ALAS1 have been thought to be associated with lipid metabolism (Gorigk et al, 2022; Lian et al, 2018; Luciani and Devuyst, 2020; Wang et al, 2014a; Yao et al, 2018).