In the article published in the last issue of EMBO Molecular Medicine, Verhoeven and collaborators unveil how the ablation of autophagy promotes the acquisition by tumor endothelial cells (TECs) of a nuclear factor κB (NF-κB)-dependent inflammatory phenotype that, supporting CD8+ T-cell infiltration and activity, promotes the response of cutaneous melanoma to ICB therapy with anti-PD-1 (Verhoeven et al, 2023). The gene discussed is CD8A; the disease is neoplasm.