TP53 and Li-Fraumeni syndrome: Of note, patients with aneuploid cB-ALL, except for patients with HoL-B-ALL mostly diagnosed with Li-Fraumeni syndrome harboring TP53 mutations (Molina et al, 2021b), clustered together in Uniform Manifold Approximation and Projection (UMAP) analyses (Fig. 7D), suggesting that, irrespective of their clinical outcome, aneuploidy makes a significant contribution to the transcriptomic signature of aneuploid subtypes of cB-ALL.