Four high-confidence IP genes were found, all of which were highly expressed in higher-risk patients: gap junction GJB2 involved in non-syndromic hearing impairments (Snoeckx et al, 2005), voltage-gated sodium channel SCN9A involved in pain sensation in peripheral nervous system (Cox et al, 2006), aquaporin AQP9 with roles in kidney cancer (Xu et al, 2019), and calcium-activated potassium channel KCNN4 with roles in GBM (D’Alessandro et al, 2013; Grimaldi et al, 2016; Hausmann et al, 2023). This evidence concerns the gene SCN9A and kidney cancer.