Cancer proliferation and invasion genes were downregulated, including proliferation marker gene MKI67 with prognostic value in glioma (Torp, 2002), nerve growth factor receptor NGFR involved in GBM invasion (Ahn et al, 2016), and long non-coding RNA MALAT1 with tumor suppressive function in GBM (Han et al, 2016) (Fig. 4E). This evidence concerns the gene MALAT1 and glioma.