Of note, MYC-p53−/− but not MYC-Apc−/−, MYC-Cdh1−/− or MYC-Pten−/− tumors harbored recurrent genomic rearrangements, consistent with the CIN subtype of human gastric cancer (Fig. 2e–f and Extended Data Fig. 5p,q). This evidence concerns the gene CDH1 and gastric cancer.