Conversely, overexpression of PEDF in the PFC has been shown to induce antidepressant “like” behaviors, by exerting effects on the tryptophan and glutamate in the PFC, with tryptophan being an essential amino acid precursor of serotonin, which is known to be associated with both depression and SB [104]. The gene discussed is SERPINF1; the disease is depressive symptom measurement.