For the 142 intact CHM1 LINE-1s that we tested for in vitro activity, we compared our Hamming-distance-based in vivo fitness to the somatic 3’ transduction counts from several cancer genome panels (Tubio et al, 2014; Rodriguez-Martin et al, 2020; Chuang et al, 2021) (Dataset EV1, columns Y, Z and AA). This evidence concerns the gene CNMD and cancer.