Consistent with WSB2 mRNA expression in the liver cancer (LIHC) cohort in the UALCAN database (Supplementary Fig. 3a, b) and Gene Expression Omnibus (GEO) database (Supplementary Fig. 3c–f), WSB2 expression was markedly increased in HCC tumor tissues compared to the matching adjacent normal liver tissues at both the mRNA level (Fig. 1a) and protein level (Fig. 1b, c). Here, WSB2 is linked to neoplasm.