A study involving 612 health-screened subjects found elevated circulating CHI3L1 levels in 86 subjects (406.7 ± 286.6 ng/mL) with PAD, and this finding was positively correlated with inflammatory biomarkers, suggesting that the level of circulating CHI3L1 is significantly associated with the risk of peripheral artery disease139. The gene discussed is CHI3L1; the disease is peripheral arterial disease.