PPT1 is markedly upregulated in cancer and can effectively control tumor growth19.The ABHD17 family (including ABHD17A, ABHD17B, and ABHD17C), which belongs to the α/β-hydrolase folding superfamily20, catalyzes cancer-promoting N-Ras depalmitoylation and facilitates its repositioning to the endosomal membrane; accordingly, the ABHD17 family may impede the development of tumors21. The gene discussed is NRAS; the disease is cancer.