The effect on let-7 family members seems to be mediated by B. vulgatus-A2 CFS; in fact, a significant decrease of circulating let-7e-5p was reported between controls and samples taken <1 year before tissue transglutaminase antibodies positivity.48 In addition, our data demonstrated the ability of B. vulgatus-A2 CFS treatment to specifically affect miR-152-3p expression as indicated by less upregulation of this miRNA in PCeD organoids compared to HC organoids before and after B. vulgatus-A2 CFS treatment. The gene discussed is TGM2; the disease is myalgic encephalomeyelitis/chronic fatigue syndrome.