ACE and COVID-19: Ajala et al. reported that (0.39) were homozygous for the ACE1 D allele, (0.14) were homozygous for the I allele and (0.47) were heterozygous (I/D) in Brazilian healthy children.33 Park et al. reported that genotype frequencies of ACE1 D/D were 17.5%, I/D 45.0% and I/I 37.5% in Korean hypertensive adolescents.22 A recent meta-analysis performed by Aziz and Islam included 11 studies which investigated the distribution of ACE I/D rs1799752 alleles in different populations and evaluated the association between ACE I/D rs1799752 polymorphism and COVID-19 severity.