ACE and infection: In accordance with our results, recent studies reported that the D allele of ACE1 and DD genotype is integrally involved in susceptibility to SARS-CoV-2 infection and COVID-19 progression, meanwhile the ACE1-II genotype negatively correlates with infection rate and hospital mortality.27,28 Verma et al. reported that carrying the ACE1 D/D genotype was associated with a 3.6-fold higher risk of severe COVID-19 in Indian population.29