ACE2 and COVID-19: In sharp contrast, ACE2 converts angiotensin II into Angiotensin 1–7 which binds to Mas receptors to counteract the negative effects of Angiotensin II.8 Several studies reported that down-regulation of ACE2 expression and increased Angiotensin II production during SARS-CoV2 infection resulted in severe lung injury, suggesting a crucial role of RAS and associated signaling cascade in the pathogenesis and progression of COVID-19.9,10