Therefore, combining previous studies with our results, quercetin may inhibit the migration and invasion of hypopharyngeal squamous cell carcinoma cells by regulating the PI3K-Akt signaling pathway, thus prolonging the overall survival of patients with hypopharyngeal carcinoma, which is also one of the directions of our subsequent studies. This evidence concerns the gene AKT1 and hypopharynx squamous cell carcinoma.