Among them, the hub targets whose up-regulated expression could improve the overall survival rate of hypopharyngeal cancer patients included IL2, IL10, BCL2, CDKN2A, CXCR4, PTK2B, and TNF; the hub targets whose down-regulated expression could improve the overall survival rate of hypopharyngeal cancer patients included AKT1, CCND1, CXCL8, EGFR, CDKN1A, BIRC5, GAPDH, MET, MYC, and TGFB1. Here, PTK2B is linked to hypopharynx cancer.