Among them, the hub targets whose up-regulated expression could improve the overall survival rate of hypopharyngeal cancer patients included IL2, IL10, BCL2, CDKN2A, CXCR4, PTK2B, and TNF; the hub targets whose down-regulated expression could improve the overall survival rate of hypopharyngeal cancer patients included AKT1, CCND1, CXCL8, EGFR, CDKN1A, BIRC5, GAPDH, MET, MYC, and TGFB1. This evidence concerns the gene CDKN2A and hypopharynx cancer.