Among them, the hub targets whose up-regulated expression could improve the overall survival rate of hypopharyngeal cancer patients included IL2, IL10, BCL2, CDKN2A, CXCR4, PTK2B, and TNF; the hub targets whose down-regulated expression could improve the overall survival rate of hypopharyngeal cancer patients included AKT1, CCND1, CXCL8, EGFR, CDKN1A, BIRC5, GAPDH, MET, MYC, and TGFB1. The gene discussed is TNF; the disease is hypopharynx cancer.