Then we investigated genes associated with immune response through TIMER database, we found AP3M2 was positively related with FOXP3(r = 0.18), CD72(r = 0.16), RUNX1(r = 0.33), LAG3(r = 0.19), CTLA4(r = 0.24) PD-L1(CD274) (r = 0.27), CD20(MS4A1) (r = 0.13), PD1(CD279, PDCD1) (r = 0.15) and irrelated with CD19 in colon cancer. This evidence concerns the gene LAG3 and malignant colon neoplasm.