In our study, FOXP3(r = 0.179), CD72(r = 0.155), RUNX1(r = 0.327), LAG3(r = 0.194), CTLA4(r = 0.236) have a positive correlation with AP3M2 in Colon Neoplasm, but no irrelevancy in rectal tumor. The gene discussed is RUNX1; the disease is rectal neoplasm.