AP3M2 plays different roles in various cancers, it is an oncogene in Breast invasive carcinoma, Cholangiocarcinoma, Stomach adenocarcinoma, Colon adenocarcinoma, Rectum adenocarcinoma, Esophageal carcinoma, Head and Neck squamous cell carcinoma, Liver hepatocellular carcinoma and Lung squamous cell carcinoma. This evidence concerns the gene AP3M2 and head and neck squamous cell carcinoma.