STK11 and non-small cell lung carcinoma: To further demonstrate the inhibitory effect of HY041004 was dependent on JOSD2-LKB1 axis, we treated LKB1-null NSCLC cell lines with HY041004, and found the susceptibility of these five LKB1-null cell lines towards HY041004 were less than that in LKB1 wild-type NSCLC cell lines (Fig. 8a, Supplementary Fig. S10a).