Among these DUBs, 10 DUBs including USP7, USP22, USP38, JOSD2, USP33, USP12, USP47, USP43, USP33 and STAMBPL1 displayed a negative correlation with OS in NSCLC patients, suggesting potential tumor-promoting roles in NSCLC (Fig. 1a, b and Supplementary Fig. S1a, b). This evidence concerns the gene USP22 and neoplasm.