Mechanistically, JOSD2-mediated removal of K6-linked polyubiquitination on LKB1 lysine residues 191, 269 and 423 resulted in disruption of LKB1-STRAD-MO25 complex integrity and inhibition of LKB1 kinase activity in NSCLC. This evidence concerns the gene JOSD2 and non-small cell lung carcinoma.