A recent study revealed that in hepatocellular carcinoma, K63-linked polyubiquitination on LKB1 by Skp2-SKP1/Cullin/F-box (SCF) ubiquitin ligase is critical for maintaining LKB1-STRAD-MO25 complex integrity and LKB1 activation.18 However, it remains elusive whether similar ubiquitination event can dictate the complex integrity and kinase activity of LKB1 in NSCLC models. Here, SKP2 is linked to non-small cell lung carcinoma.