Ataxin-3L has been demonstrated to be required for hepatocyte growth factor-induced growth of NSCLC.34 Recently, JOSD1 has been identified as the most significantly upregulated DUB during the development of chemo-resistance in gynecological cancer.35 JOSD1 deubiquitinates K48 linkage of myeloid cell leukemia 1 (MCL1) to stabilize its protein levels and then exerts anti-apoptosis effect. The gene discussed is ZUP1; the disease is female reproductive organ cancer.