SKP2 and hepatocellular carcinoma: A recent study revealed that in hepatocellular carcinoma, K63-linked polyubiquitination on LKB1 by Skp2-SKP1/Cullin/F-box (SCF) ubiquitin ligase is critical for maintaining LKB1-STRAD-MO25 complex integrity and LKB1 activation.18 However, it remains elusive whether similar ubiquitination event can dictate the complex integrity and kinase activity of LKB1 in NSCLC models.