To identify the DUB most closely associated with NSCLC cell growth, we knocked down these DUBs one by one in 3 NSCLC cell lines including NCI-H1299, NCI-H358 and PC-9, and then compared their inhibitory effects on cell growth, and found that depletion of JOSD2 posed a strong inhibitory effect on these 3 cell lines (Fig. 1c). The gene discussed is JOSD2; the disease is non-small cell lung carcinoma.