However, in addition to LKB1, the previously reported substrate of JOSD2, such as PHGDH,7,8 could not be excluded in the process that HY041004 arrested NSCLC proliferation, as this compound also displayed some activities in LKB1-null cells A549 and NCI-H460, with a less robust extent compared to those LKB1-WT cells. The gene discussed is JOSD2; the disease is non-small cell lung carcinoma.