CTSB and non-small cell lung carcinoma: JOSD2 belongs to the MJD subfamily of DUBs along with other three cysteine-proteases, Ataxin-3, Ataxin-3L and JOSD1.6 Furthermore, data mining using TCGA database showed that the mRNA levels of JOSD2 and Ataxin-3 was significantly elevated in NSCLC compared to normal tissue, to a greater extent than that of the other MJD members, but only JOSD2, not JOSD1 and Ataxin-3, was significantly associated with poor overall survival of NSCLC patients (Supplementary Fig. S1b–d).