Subsequently, we silenced endogenous JOSD2 in multiple NSCLC cell lines (NCI-H1299, PC-9, NCI-H2347, NCI-H2228, NCI-H292 and NCI-H358) and found that JOSD2 depletion significantly inhibited the cell proliferation and colony formation in these NSCLC cells, but impose minimal effect on human normal lung epithelial cells BEAS-2B (Fig. 1e, f and Supplementary Fig. S2b, c). The gene discussed is JOSD2; the disease is non-small cell lung carcinoma.