Our comprehensive transcriptomic analysis identified B-lymphocyte kinase (BLK) and lymphocyte-specific protein tyrosine kinase (LCK) as kinases that were upregulated in the DSRCT CSC model, controlled by the EWSR1-WT1 fusion gene, and expressed more highly in recurrent versus primary DSRCT tumors. Here, BLK is linked to desmoplastic small round cell tumor.