To identify other genes regulated by LINC02454 that govern glioma cell sensitivity to TMZ, we analyzed RNA-seq data of LINC02454 KD and OE U251 glioma cells and U251 glioma cells treated with TMZ (50 μM) for 0, 4, 9,12, and 16 days [34] (Fig. 6B, C). This evidence concerns the gene LINC02454 and central nervous system cancer.