Moreover, relative to control TMZ-treated U251 cells, caspase 3/7 activities markedly decreased in TMZ-treated KO#1 and KO#2 cells at 48 and 72 h time points (Fig. 4E, F), suggesting an overall decrease in glioma TMZ sensitivity in LINC02454 SE KO cells. Here, CASP3 is linked to glioma.