Among them, 11 were upregulated in LINC02454 KD glioma cells and downregulated in LINC02454 OE cells (Fig. 6B), while 21 were downregulated in LINC02454 KD glioma cells and upregulated in LINC02454 OE cells (Fig. 6C). This evidence concerns the gene LINC02454 and central nervous system cancer.