Additionally, LysMCreCul5fl/fl mice injected with OSMI-1 showed signs of aggravated asthma exacerbations, including deteriorated AHR (Fig. 5d), increased mucus deposition, tissue destruction, cell infiltration, and collagen accumulation (Fig. 5e and Supplementary Fig. 8f), and higher total BALF cell counts (Fig. 5f) and serum IgE levels (Fig. 5g), compared with LysMCreCul5fl/fl mice treated with the control vehicle. The gene discussed is IGHE; the disease is asthma.