To test this hypothesis, we intranasally treated the influenza-induced asthma exacerbations LysMCreCul5fl/fl mice with an IFN-β neutralizing antibody (anti-IFN-β Ab) (Fig. 3d), which reaggravated mucus deposition, tissue destruction, cell infiltration, and collagen accumulation (Fig. 3e and Supplementary Fig. 6f). This evidence concerns the gene IFNB1 and asthma.