IFN-β expression was markedly suppressed, and the expression of viral M protein was further induced in LysMCreCul5fl/fl asthma exacerbation mice injected with OSMI-1 compared to that in LysMCreCul5fl/fl asthma exacerbation mice treated with the control vehicle (Fig. 5b, c). This evidence concerns the gene IFNB1 and asthma.