Additionally, the expression of Il4 and neutrophilic inflammatory cytokines including Tgfb, Tnfa, Cxcl15, Elane, and Mmp9 in asthma exacerbation mice were markedly lower in LysMCreCul5fl/fl mice than in Cul5fl/fl mice (Fig. 2i). The gene discussed is IL4; the disease is asthma.