Collectively, our results demonstrate that CUL5, which is upregulated by the epithelial alarmin TSLP in allergic asthma, can contribute to the “insensitive” state of AMs by inhibiting IFN-β production following the viral infection and driving the development of virus-induced asthma exacerbations (Fig. 9). The gene discussed is IFNB1; the disease is viral infectious disease.