To identify novel regulators of PPARγ, co-immunoprecipitation (CoIP) experiments were performed in cytoplasmic lysates from the aneuploid CIN+ human CRC cell line SW480 [53] followed by silver staining and sequencing by mass spectrometry (MS) [41] (Fig. 1A). Here, PPARG is linked to cervical squamous intraepithelial neoplasia.