Impaired survival is most prominent in patients with a MYC-R combined with a rearrangement of the BCL2 and/or BCL6 gene (so-called ‘double hit’ [DH] and/or ‘triple hit’ [TH] high-grade B-cell lymphoma (DH/TH HGBL), especially when the fusion partner of MYC is the IgH locus [9]. Here, MYC is linked to B-cell non-Hodgkin lymphoma.