The NLRP3 inflammasome mediates pulmonary fibrosis through the IL-1β-IL-1Rs-MyD88-NF-κB signaling pathway.263 Moreover, studies also found that NLRP3 inflammasome could transform lung endothelial cells into epithelial-mesenchymal transition, promoting pulmonary fibrosis. The gene discussed is MYD88; the disease is pulmonary fibrosis.