NLRP3 and neoplasm: Several commonly used medications like anti-tumor drugs (i.e. doxorubicin) and antipsychotic drugs are reported to have significant cardiotoxic effects.194,195 Moreover, a recent study found that Sirtuin 3 alleviates the doxorubicin-induced cardiotoxicity by inhibiting the activation of the NLRP3 inflammasomes.196 Antipsychotic cardiotoxicity was predominantly mediated by CB1R translocation-induced NLRP3 inflammasome stabilization and subsequent pyroptotic cell death.115 These findings indicate that inflammasome activation may act as a mediator of drug-induced toxicity.