In addition, curcumin could induce the expression of AIM2, NLRC4, and IFI16 inflammasomes in leukemia cells U937, which subsequently activated caspase 1, promoted GSDMD cleavage, as well as induced pyroptosis.340 Altogether, targeting the inflammasomes could have therapeutic effects on leukemia. The gene discussed is NLRC4; the disease is leukemia.