J114, a chemical compound, disrupted interactions of NLRP3 or AIM2 with ASC and suppressed ASC oligomerization.409 It has been found that Caffeic acid phenethyl ester (CAPE) can directly bind to ASC, thereby preventing NLRP3-ASC interactions that are triggered by MSU crystals.410 A study involving a mouse model of gouty arthritis induced by MSU crystals showed that oral administration of CAPE resulted in a decrease in caspase-1 activation and IL-1β release in foot tissue and air pouch exudate. The gene discussed is PYCARD; the disease is gout.