NLRP3 and caspase-1 are significantly higher in ALL cells resistant to glucocorticoids, as caspase-1 cleaves the glucocorticoid receptor.338 In contrast, NLRP3 expression was significantly lower in CLL lymphocytes than in healthy donors, whereas P2X7R expression was higher.339 Aside from activating NLRP3 inflammasomes, P2X7R also inhibits apoptosis and promotes cell proliferation.339 NLRP3 downmodulation triggers P2X7R expression, which consequently leads to tumor growth. The gene discussed is CASP1; the disease is B-cell chronic lymphocytic leukemia.