NLRP3 and ovarian endometriosis: Studies have shown that NLRP3 levels are higher in ovarian endometriosis samples, and using MCC950 to inhibit NLRP3 has been shown to decrease IL-1β concentrations in cyst-derived stromal cells.334 The results suggested that NLRP3/IL-1β is crucial for the pathogenesis of endometriosis.