NLRP3 and male reproductive organ cancer: In another study, Trichomonas vaginalis stimulation was shown to increase the expression of NLRP3, ASC, Caspase-1, and IL-1β, while inhibition of NLRP3 and Caspase-1 decreased the T. vaginalis-induced IL-1β secretion in a prostate epithelial cell line (RWPE-1).329 These studies provide evidence that the NLRP3 inflammasome is associated with the development of prostatitis.