Patients with systemic lupus erythematosus (SLE) suffer from disordered Th1/Th2 and Treg/Th17 balances, evidence has demonstrated that NLRP3, NLRP1, NLRC4, and AIM2 were involved in the regulation of Th1, Tfh, and Th17 cell-mediated immune responses. The gene discussed is NLRP1; the disease is systemic lupus erythematosus.