This is characterized by significantly increased levels of IL-18 in lymphoma tissues, which is positively correlated with the expression of programmed death ligand 1 (PD-L1).345,346 PD-L1 is induced by NLRP3 inflammasome activation, and this reduces the proportion of cytotoxic T cells in DLBCL cell lines. This evidence concerns the gene CD274 and diffuse large B-cell lymphoma.