CASP1 and myeloproliferative neoplasm: Analysis of patients showed that the IL-1β levels were increased in all three different types of myeloproliferative neoplasms.341 Moreover, JAK2V617F positive macrophages produced greater IL-1β and IL-18, which promoted the production and activation of neutrophils and the entry of leukocytes into lesion.342 Additionally, AIM2, IL-1β, and caspase-1 were significantly increased in JAK2V617F positive cells.343 This data indicates that inflammasomes are vital in the pathogenesis of myeloproliferative neoplasms.