Upon rotavirus infection, NLRP9b forms inflammasomes with ASC and caspase-1 to trigger the maturation of IL-18 and GSDMD-induced pyroptosis in mice.17 NLRP9b-, ASC-, or caspase1- deficient mice exhibit elevated viral loads and pathological symptoms than wild-type mice, suggesting that NLRP9b could initiate inflammasome formation upon rotavirus infection. The gene discussed is IL18; the disease is Rotavirus infection.