NLRP6 expression is downregulated when nephrotoxic kidney injury occurs.307 NLRP6 deficiency is believed to exacerbate the severity of AKI by inhibiting the phosphorylation of ERK1/2 and p38 MAPK, and suppressing the nephroprotective gene Klotho expression.308 NLRC4 expression is increased after IRI. This evidence concerns the gene NLRC4 and acute kidney injury.