Additionally, in human monocytes, anti-dsDNA antibodies can activate the NLRP3 inflammasome and cause the secretion of IL-1β, further contributing to the pathogenesis of SLE.353,354 Research has shown that AIM2 can encourage the production of B cells in patients with SLE.355 People with SLE tend to have higher levels of AIM2 mRNA in their liver, PBMCs, and spleen than healthy individuals. The gene discussed is NLRP3; the disease is systemic lupus erythematosus.