PYCARD and acute myocarditis: During the healing phase, ASC aggregates are most prevalent in cardiomyocytes and fibroblasts.186,187 Furthermore, patients with acute myocarditis have been found to have NLRP3 inflammasomes in their endomyocardium.188 CVB3, a common virus causing myocarditis, increases caspase-1, ASC, and IL-1β expression in infected mice by altering NLRP3 activation.189 Mechanistically, Cathepsin B mediates both inflammasome activation and pyroptosis in experimental CVB3-induced myocarditis.190