PYCARD and rheumatoid arthritis: It was observed that the levels of serum AIM2 were lower in RA patients compared to healthy controls; however, ASC, caspase-1, and IL-1β levels were higher.363 Individuals diagnosed with RA have elevated levels of mDNA in their plasma and synovial tissue compared to healthy individuals.364 They also have a higher chance of activating AIM2 inflammasomes.