NLRP3, encoded by RS772009059 (R779C), in 3 patients showed early-onset IBD.56 A positive correlation was also found between the incidence of severe diseases and NLRP3 inflammasome activity in macrophages when R779C is present in DSS-induced acute colitis models.56 More studies on how the NLRP3 inflammasome regulates inflammation will inspire new approaches to therapeutics for IBD. Here, NLRP3 is linked to inflammatory bowel disease.