Additionally, in human monocytes, anti-dsDNA antibodies can activate the NLRP3 inflammasome and cause the secretion of IL-1β, further contributing to the pathogenesis of SLE.353,354 Research has shown that AIM2 can encourage the production of B cells in patients with SLE.355 People with SLE tend to have higher levels of AIM2 mRNA in their liver, PBMCs, and spleen than healthy individuals. Here, AIM2 is linked to systemic lupus erythematosus.