NLRP3 and acute kidney injury: NLRP3 inflammasome activation and mitochondrial damage were detected in IR-induced AKI model mice, and damaged mitochondria further activate the NLRP3 inflammasome via the mROS-TXNIP-NLRP3 pathway.301 NLRP3 deletion protected the kidney from further inflammatory damage and injury.302 Moreover, pyroptosis also occurred in tubular epithelial cells of renal IRI mice.303 Another study discovered that protection from IRI was observed in NLRP3 knockout mice, but not in ASC knockout or caspase-1 knockout mice.