NLRP3 and type 2 diabetes mellitus: In addition, it has been found that saturated fatty acids can also trigger T2D by activating the NLRP3 inflammasome.376 The NLRP3 inflammasome can sense ceramide, which is a type of saturated fatty acid, leading to the activation of caspase-1 in mouse bone marrow-derived macrophages and epididymal adipose tissue explants.377 On the other hand, unsaturated fatty acids have been shown to enhance insulin sensitivity by decreasing the production of IL-1β.276