NLRP3, caspase-1, pro-IL-1β, and pro-IL-18 activation were observed in a mouse model of acute pancreatitis.287 Additionally, Inhibition of P2X7R could reduce chronic pancreatic inflammation and fibrosis by attenuating NLRP3-mediated IL-1β and IL-18 secretions in a mouse model of chronic pancreatitis.288 The NLRP3 inflammasome is also believed to contribute to the development of fibrosis in patients with chronic pancreatitis. This evidence concerns the gene CASP1 and chronic pancreatitis.