MSU crystals are a typical DAMP that induced the NLRP3 inflammasome activation, and the IL-1β release is vital in the initiation of inflammatory gout attacks or flares.367 MSU stimulation resulted in decreased knee neutrophil infiltration in mice lacking critical components of inflammasomes (NLRP3, ASC, or caspase-1).368 An endogenous DAMP, cold-inducible RNA-binding protein, activates MSU-stimulated neutrophil infiltration via an NLRP3/ASC/caspase-1/IL-1β/MyD88 pathway-mediated CXC-motif receptor 2-dependent process.369. Here, PYCARD is linked to gout.