NLRP3 and acute lymphoblastic leukemia: Nevertheless, experiments with KrasG12D murine models have demonstrated that NLRP3 deficiency can reverse these effects.336 Patients newly diagnosed with AML have also been found to have increased NLRP3 expression in their bone marrow mononuclear cells and their peripheral blood mononuclear cells (PBMCs).337 Glucocorticoids are often used to treat patients with ALL.