PSEN1 and Alzheimer disease: Furthermore, the ASC speck formation is another feature of inflammasome activation, and upon release, the ASC specks bind quickly to Aβ peptides.216 Aβ was also shown to bind with ASC in brain samples from AD and APP/PS1 mice.216 Moreover, ASC specks can seed Aβ deposition in APP/PS1 mice.217 These findings suggest that the release of ASC specks may contribute to early Aβ deposition and the pathogenesis of AD.