It has been found that IFI16 interacts with ASC, but not AIM2 or NLRP3, and subsequently procaspase-1, to form an effective inflammasome in KHSV.350 Another study reported that mutations in IL-18 (rs1946518) and NFκB-94 ins/del (rs28362491) promoted the susceptibility to B-cell NHL.345,351 Additionally, allele G in IL-18 was shown to be remarkably associated with the risk of lymphoma.345 These findings show that specific inflammasomes play different roles in lymphoma development. Here, PYCARD is linked to lymphoma.