AIM2 and systemic lupus erythematosus: Additionally, AIM2 drives a form of inflammatory signaling and cell death, known as PANoptosis, by regulating the innate immune sensors ZBP1 and pyrin.151 AIM2 has also been shown to have permissive ligand requirements, as bacteria and cytosolic dsDNA from viruses or the host can activate AIM2.152 As a result, it has been suggested that AIM2 is involved in self-DNA-induced autoimmune responses in systemic lupus erythematosus.