During NSCLC progression, circRNA C190 promotes cell proliferation via modulating the EGFR/MAPK/ERK signaling pathway [204]; circ-ZKSCAN1 accelerates proliferation and progression through sponging miR-330-5p to upregulate FAM83A expression and subsequent inactivation of MAPK signal transduction pathway [205]; circular RNA 0001313 (circ0001313) promotes NSCLC cell proliferation and invasion through serving as a microRNA-452 sponge to regulate HMGB3/ERK/MAPK axis [206]. Here, MAPK1 is linked to non-small cell lung carcinoma.