Growing evidence has demonstrated that circRNAs can modulate the interplay between inflammation and tumorigenesis through various regulatory mechanisms, such as sponging miRNAs, binding to RBPs, and encoding proteins to regulate inflammatory signaling pathways involves in cancer progression, including NF-κB, PI3K-AKT, MAPK, JAK-STAT, etc [232, 233]. The gene discussed is NFKB1; the disease is cancer.