In lung adenocarcinoma (LUAD), circPIBF1 binds to nuclear factor erythroid 2-related factor 2 (Nrf2), which further promotes SOD2 expression and recruits EP300 to promote H3K27ac modification of SOD2, thus modulating the Nrf2/Keap-1 pathway and participating in pyroptosis-related carcinogenesis process [220]. Here, NFE2L2 is linked to lung adenocarcinoma.