In hepatocellular carcinoma, circDHPR facilitates tumor growth and metastasis through interacting with miR-3194-5p to target the RASGEF1B/RAS/MAPK signaling pathway [198]; circASAP1 promotes cell proliferation and invasion via acting as the sponge of miR-326 and miR-532-5p to regulate MAPK1 expression [199]; circSETD3 inhibits tumor growth through targeting miR-421/MAPK14 signaling pathway [200]. Here, RASGEF1B is linked to neoplasm.