HAVCR2 and neoplasm: As for the regulation of TIM-3, Zhang et al. reported that under the setting of hepatocellular carcinoma, circUHRF1 upregulated the expression of TIM-3 in NK cells by sponging miR-449c-5p, and inhibited the secretion of IFN-γ and TNF-α by NK cells, thus promoting tumor immune escape [295].