In the context of colitis-associated colorectal carcinoma (CAC), PRKAR2A-derived circRNA (mmu_circ_0001109) exacerbates the colitis progression through activating the JAK-STAT3 and NF-κB signaling pathways, and promotes the transition of inflammation to carcinoma via activating the Wnt/β-catenin signaling pathway [236]. The gene discussed is STAT3; the disease is colitis.