A recent publication demonstrated that heat shock protein 90 alpha (HSP90A) derived circHSP90A was significantly upregulated in NSCLC and could facilitate cell growth, stemness, and immune evasion by recruiting ubiquitin specific peptidase 30 (USP30) to further stabilize HSP90A protein, which then activates the STAT3 signaling pathway. The gene discussed is HSP90AA1; the disease is non-small cell lung carcinoma.