NFKB1 and cancer: Additionally, the nuclear factor-kappaB (NF-κB) signaling is also considered as a proliferation related pathway in cancer, and multiple circRNAs, such as circ_0001821, hsa_circ_0021727 (circ-CD44), ciRS-7, circCYP24A1, circZFR, circLIFR, circCORO1C, circADAMTS6, circ_0002019, circGLIS2, circINTS4, circARHGEF28, circ_0001461, have been reported to regulate cell proliferation through modulation of NF-κB signaling axis in different tumors [165] (Fig. 7).