For instance, circ-TPGS2 promotes tumor-associated inflammation, cell dissemination and metastasis of breast cancer through serving as a miR-7 sponge to increase TRAF6 expression, contributing to p65 phosphorylation and nuclear translocation, ultimately inducing the activation of NF-κB signaling pathway and dysregulation of tumor microenvironment [234]. Here, TRAF6 is linked to neoplasm.