ITCH and lung cancer: For instance, in the context of lung cancer, circ-EIF3I facilitates cell proliferation by targeting miR-1253/NOVA2 to regulate Wnt/β-catenin pathway; circVAPA promotes cell proliferation by targeting miR-876-5p/WNT5A to activate Wnt/β-catenin signaling; circ-ZNF124 enhances cell proliferation via miR-498/YES1 axis to activate Wnt/β-catenin signaling pathway; cir-ITCH suppresses tumor proliferation by serving as the sponge of miR-7 and miR-214 to upregulate ITCH and then inactivate Wnt/β-catenin pathway [179–182].