In esophageal cancer, circVRK1/miR-624-3p/PTEN, circLARP4/miR-1323/PTEN, and circ_0007624/miR-224-5p/CPEB3 axis were confirmed to regulate PI3K/AKT signaling pathway participating in cell proliferation [145–148]. The gene discussed is PTEN; the disease is esophageal cancer.