CD274 and neoplasm: Ge et al. found that circBART2.2 encoded by Epstein-Barr virus (EBV) could bind to the helicase domain of RBP RIG-I in nasopharyngeal carcinoma (NPC) cells, and then activate the transcription factors IRF3 and NF-κB, resulting in enhanced expression of PD-L1 to induce tumor immune escape [288].