CircCORO1C, which was highly expressed in hepatocellular carcinoma, could upregulate the expression of c-Myc and COX-2 by stimulating the NF-κB pathway and enhancing P65 phosphorylation to induce PD-L1 expression, thus promoting immune escape and tumor growth [172]. The gene discussed is NFKB1; the disease is hepatocellular carcinoma.