Similar to the effect caused by tumor cGAS and host STING activation, VC treatment led to a reduction in CD31+ tumor vessels and intratumoral hypoxia, as evidenced by decreased GLUT1 expression, but an obvious increase in α-SMA+ pericyte coverage of CD31+ tumor vessels and intratumoral CD8+ T cells infiltration (Fig. 9a, Supplementary Fig. 12e). This evidence concerns the gene CD8A and neoplasm.