Although IL-2 is well known for driving T cell responses by binding to its receptors, which consists of three subunits including IL-2Rα (IL2RA), IL-2Rβ (IL2RB), and IL-2Rγ (IL2RG)29, we found that both IL2RB and IL2RG were expressed in numerous liver cancer cell lines, especially IL2RG, in CCLE database (Supplementary Fig. 8a, b) and similar results were confirmed in liver cancer samples from TCGA dataset (Supplementary Fig. 8c). This evidence concerns the gene IL2 and liver cancer.