In contrast, on the background of Sting deficiency, Cgas overexpression in Hepa1-6 cells (Cgas (+)/Sting (−)) dramatically retarded tumor growth (Fig. 1b, c) and angiogenesis, increased pericyte coverage of tumor vessels, accompanied by mitigated vascular permeability and elevated intratumoral T cell infiltration (Fig. 1d, e, Supplementary Fig. 2a, b). The gene discussed is STING1; the disease is neoplasm.