Importantly, we found that with higher Cgas expression in cancer cells, smaller tumor burdens were observed (Fig. 1m, n), while more pericyte coverage of tumor vessels and intratumoral T cell infiltration were detected (Fig. 1o), suggesting that tumor cGAS mediates tumor repression, vascular normalization, and anti-tumor immune response in a cGAS expression level-dependent manner. The gene discussed is CGAS; the disease is neoplasm.