CGAS and cancer: VC treatment resulted in much more marked formation of perinuclear Sting aggregates, which are readout for STING activation by cGAMP10,18, in Sting-Cherry-expressed endothelial cells when co-cultured with GFP-labeled Hepa1-6 cells (Fig. 7j), whereas VC treatment on endothelial cells alone neither induced more Sting aggregates nor upregulated Cgas expression (Supplementary Fig. 10a–c), implying that VC indirectly activates endothelial Sting through cancer cells.