Additionally, no obvious difference was observed in α-SMA+ pericyte coverage of CD31+ tumor vessels, which is one of the hallmarks of tumor vessel normalization15, vascular permeability, or intratumoral T cell infiltration (Fig. 1d, e, Supplementary Fig. 2a–c), indicating that tumor-intrinsic STING expression is not required for vascular normalization and anti-tumor immunity under low tumor cGAS background. This evidence concerns the gene ACTA1 and neoplasm.