CGAS and liver cancer: The murine liver cancer cell line (Hepa1-6) with low endogenous Cgas and intact Sting expression was forcedly expressed with Cgas following depletion of its Sting via CRISPER-Cas9 or not to establish three cells of same origin with Cgas (−)/Sting (+), Cgas (−)/Sting (−), and Cgas (+)/Sting (−) expression (Fig. 1a, Supplementary Fig. 1a).