JAK2 strongly inhibits the stabilization of p53 after induction of DNA damage through the increase in E3 ubiquitin-protein ligase Mdm2 (MDM2) translation, which is dependent on the phosphatidylinositol 3-kinase (PI3K)/AKT/mTOR pathway in cell lines and primary cells from MPN patients [7]. This evidence concerns the gene MDM2 and myeloproliferative neoplasm.