SLC1A2 and heart failure: Increased neurohumoral drive such as heart failure condition-induced glial remodeling caused decreased GLT1 and increased GLAST to elevate ambient glutamate level; thus, increased INMDA of SON NMCs (Potapenko et al., 2012) and similar changes in GLT1 was also observed in SON MNCs during dehydration (Fleming et al., 2011).