Given that robust NR2D protein expression in the SON MNCs is uncommon in the adult brain (Doherty and Sladek, 2011) and that NR2D generates an “Mg2+-resistant” INMDA of MNCs in a state-dependent manner (Neupane et al., 2021), we investigated whether NR2D-containing eNMDARs contribute to exacerbated INMDA in SON neurons during hypertension and whether this finding could be a mechanism contributing in turn to neurohumoral activation in this cardiovascular disease. The gene discussed is GRIN2D; the disease is Hypertension.