For example, a key mechanotransducer, transcriptional co-activator with PDZ-binding motif (TAZ), is localized to the nucleus and more highly expressed in corneal endothelial cells with Fuchs’ endothelial corneal dystrophy (FECD), specifically near the site of topographical changes in their ECM known as guttae (Leonard et al., 2023). The gene discussed is WWTR1; the disease is Fuchs endothelial corneal dystrophy.