IFNA2 and COVID-19: As previously observed in adults (Manry et al., 2022), the risk of life-threatening COVID-19 is also higher for children carrying auto-Abs neutralizing high concentrations of IFN-α2 and/or IFN-ω than for children carrying only auto-Abs neutralizing low concentrations, further suggesting that auto-Abs neutralizing high concentrations of IFN-α2 and/or IFN-ω have a more deleterious impact on COVID-19 outcomes.