TNC had missense mutations in either the initial clone or a disseminated clone of triple-proficient and chemonaive cancers (Figure 3, A and C), but only the clonal mutation was predicted to be damaging (TNCP1790L, PolyPhen-2 score, 0.99; TNCR1637C, PolyPhen-2 score, 0.38). The gene discussed is TNC; the disease is cancer.