We have shown that PVN-specific deletion of both Gqα and G11α (PVNGq/11KO), 2 homologous and ubiquitously expressed G protein α-subunits that couple receptors to PLC, recapitulates the effects of MC4R deficiency on food intake and linear growth — namely, severe obesity associated with hyperphagia and loss of the anorectic response to melanocortin agonist, along with increased linear growth (11). Here, MC4R is linked to obesity disorder.