In contrast, female pair-fed MC4RF51L mice, which also had a significant increase in body weight compared with WT mice (Figure 6D), showed no differences in glucose tolerance or random glucose or insulin levels compared with WT mice, while ad libitum fed MC4RF51L mice showed significant glucose intolerance and elevations in serum glucose and insulin levels (Figure 6, E–H). The gene discussed is INS; the disease is Glucose intolerance.