Additionally, markers of T cell function, including Tigit, Runx3, and Pdcd1, which encodes PD-1 and was recently described to be upregulated on auto-aggressive T cells in NASH, were similarly noted to be inversely related, elevated in FFC, and lowered in TTP488-treated mice (34, 35). This evidence concerns the gene TIGIT and metabolic dysfunction-associated steatohepatitis.