RUNX2 and type 1 diabetes mellitus: Consistent with restoration of bone health in our other skeletal analyses, DEGs that were downregulated in WT mice with T1D and “rescued” by Sarm1KO included key genes related to osteoblast differentiation and function, such as runt related transcription factor 2 (Runx2), FGF receptor 2 (Fgfr2), parathyroid hormone 1 receptor (Pth1r), and collagen type I alpha 1 (Col1a1), among others (Figure 7C).