Despite this, diabetic skeletal disease in WT females mirrored our results in males, including rapid suppression of cortical and trabecular bone accrual by longitudinal in vivo microCT beginning at 3 weeks of T1D (Figure 5, A–F, and Supplemental Figure 5), decreased circulating osteocalcin (–49% at week 3, Figure 5, G and H), suppression of bone formation by dynamic histomorphometry (–78% bone formation rate at week 3, Figure 5, I–K), and impaired morphology with decreased strength of the femur (–32% max load, Figure 5, L–P, and Supplemental Figure 6). This evidence concerns the gene BGLAP and diabetes mellitus.